Another promising Alzheimer’s drug trial ends in failure: ‘This one hurts’

(CNN)It’s another devastating blow in the search for a treatment for patients living with Alzheimer’s disease. “This was the closest to the finish line and early results showed not only could we improve cognitive function but also get rid of amyloid in the brain,” Isaacson said. “This was the most hopeful thing we had — in fact I have patients who are in the study, patients that are waiting to get into the trials. “This one hurts,” Isaacson said. “Alzheimer’s patients just can’t get a break.” A hypothesis and a ‘huge gamble’ The “amyloid hypothesis” says it’s the accumulation of beta-amyloid in the brain that is the primary cause of the memory-destroying disease. Studies on mice showed that removing the …